Preview

Bulletin of Shakarim University. Technical Sciences

Advanced search

Study of the release of an encapsulated biologically active additive in a model system of the artificial environment of the gastrointestinal tract

Abstract

   At present, the need for a general strengthening and immunostimulating effect has increased significantly. For their production, natural ingredients are used that do not cause negative consequences in the human body, even with prolonged use. Deterioration of environmental conditions, chronic stress, sedentary lifestyle, unbalanced diet are factors leading to a decrease in the overall resistance of the body with constant exposure. As a result, the incidence of individual organs and systems of the body (respiratory system, gastrointestinal tract) increases, hormonal regulation is disturbed, and the immunological forces of the body decrease. In this regard, biological additives derived from medicinal plants used for the prevention and treatment of immunodeficiency conditions are especially popular. Herbal preparations compare favorably with synthetic analogues with their mild therapeutic effect, as well as the absence of obvious side effects. For the experiment, encapsulated biologically active additives (BAA) were placed in a model environment of gastric juice at pH 2.0 for 2 hours, and then the capsules were transferred into a model environment of the small intestine at pH 7.2 for 3 hours. This diagram simulates a model of the gastrointestinal tract.

About the Author

A. M. Muratbayev

Kazakhstan


References

1. Зубарева Е.В. Содержание дубильных веществ в растениях, применяющихся в официальной и народной медицине / Е. В. Зубарева, Е. Ю. Екимова, М. А. Ставцева // Новая наука: современное состояние и пути развития. – 2015. – № 4-2. – С. 17-21.

2. Куркин В. А. Флавоноиды как биологически активные соединения лекарственных растений / В. А. Куркин, А. В. Куркина, Е. В. Авдеева // Фундаментальные исследования. – 2013. – № 11 (часть 9). – С. 1897-1901.

3. Бутова С. Н. Перспективы использования сапонинов в пищевой и косметической промышленности (обзор) / С. Н. Бутова, В. А. Сальникова // Вестник Российской академии естественных наук. – 2015. – № 1. – С. 82-84.

4. Manach, C., Williamson G., Morand C., Scalbert A., Remesy C. (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies, Am. J. Clin. Nutr., 81, 230S–242S.

5. Макарова, М. Н. Биодоступность и метаболизм флавоноидов / М. Н. Макарова // Эксперим. и клин. фармакол. – 2011. – Т. 74, – № 6. – С. 33-40.

6. Sabitha P., Vijaya Ratna J. and Ravindra Reddy K. Design and evaluation of controlled release chitosan-calcium alginate microcapsules of antituber-cular drugs for oral use // Int. J. Chem. Technol. Res. 2010. – Vol. 2. – No.1. – P. 88-98.

7. Постраш Я. В. Микрокапсулирование в фармации – современное состояние и перспективы / Я. В. Постраш, О. М. Хишова // Вестник фармации. – 2010. – № 2 (48). – С. 1–7.


Review

For citations:


Muratbayev A.M. Study of the release of an encapsulated biologically active additive in a model system of the artificial environment of the gastrointestinal tract. Bulletin of Shakarim University. Technical Sciences. 2022;(1(5)):35-38. (In Kazakh)

Views: 168


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2788-7995 (Print)
ISSN 3006-0524 (Online)
X