COMPOSITE MATERIALS BASED ON CELLULOSE DERIVATIVES: PROSPECTS IN THE TREATMENT OF TROPHIC ULCERS

Chronic wounds pose a serious challenge to modern medicine. There is now a trend towards an increase in the number of patients with diabetic foot wounds. Therefore, the development of dressing materials with ideal characteristics is one of the key tasks in modern medicine. Cellulose is a promising material for the development of wound dressings due to its biocompatibility, availability and environmental friendliness. The aim of this article is to review the studies on hydrogels and films based on cellulose derivatives and its compositions for wound covering published in the scientific literature over the past decades. Particular attention is paid to materials containing bentonite and its influence on the mechanical, sorption and biomedical properties of dressings. An analysis of domestic and foreign studies devoted to composite materials based on carboxymethyl cellulose (CMC) and bentonite was conducted. Analysis of the research available to date shows that the introduction of bentonite into polymer matrices helps to increase the mechanical strength, moisture absorption capacity and structural stability of the coatings. The inclusion of clay particles allows for the regulation of the release of medicinal substances, thus increasing the effectiveness of the therapeutic effect. Studies conducted by Kazakhstan scientists confirm the potential of using local bentonite clays in the development of dressings. The development of composite hydrogels and films based on cellulose and bentonite derivatives opens new possibilities for creating effective biocompatible wound dressings. Further research should be aimed at optimizing their composition and structure to improve functional characteristics and therapeutic effectiveness.

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