КОМПОЗИЦИОННЫЕ МАТЕРИАЛЫ НА ОСНОВЕ ПРОИЗВОДНЫХ ЦЕЛЛЮЛОЗЫ: ПЕРСПЕКТИВЫ В ЛЕЧЕНИИ ТРОФИЧЕСКИХ ЯЗВ

Хронические раны представляют серьезную проблему для современной медицины. В особенности сейчас можно наблюдать тенденцию увеличения числа пациентов с диабетическими ранами стопы. Поэтому разработка перевязочных материалов с идеальными характеристиками является одной из ключевых задач в современной медицине. Целлюлоза представляет собой перспективный материал для разработки раневых покрытий благодаря своей биосовместимости, доступности и экологичности. В данной статье поставлена цель проведения обзора исследований по гидрогелям и пленкам на основе производных целлюлозы и ее композиций для покрытия ран, опубликованных в научной литературе за последние десятилетия. Особое внимание уделено материалам, содержащим бентонит, и его влиянию на механические, сорбционные и биомедицинские свойства перевязочных покрытий. Проведён анализ отечественных и зарубежных исследований, посвящённых композитным материалам на основе карбоксиметилцеллюлозы (КМЦ) и бентонита. Анализ, имеющихся на сегодняшний день исследований показывает, что введение бентонита в полимерные матрицы способствует увеличению механической прочности, влагопоглощающей способности и структурной стабильности покрытий. Включение глинистых частиц позволяет регулировать процесс высвобождения лекарственных веществ, повышая таким образом эффективность терапевтического воздействия. Исследования, проведенные Казахстанскими учеными, подтверждают перспективность использования местных бентонитовых глин в разработке перевязочных материалов. Развитие композитных гидрогелей и плёнок на основе производных целлюлозы и бентонита открывает новые возможности для создания эффективных биосовместимых раневых покрытий. Дальнейшие исследования должны быть направлены на оптимизацию их состава и структуры для повышения функциональных характеристик и терапевтической эффективности.

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