DETERMINATION OF OPTIMAL ACTIVITY OF RADIOACTIVE IODINE 131 AT TREATMENT OF THYROID CANCER OF POPULATION OF REPUBLIC OF KAZAKHSTAN

This article is devoted to the problem of a high level of oncological diseases of the population of the Republic of Kazakhstan. The analysis of the presented statistical data indicates an annual increase in the number of detection of registered oncological diseases in the population of the Republic of Kazakhstan. With regard to our region, the annual increase in the number of cancer detection in the population of the Abai region, which is undoubtedly due to the existence of the former Semipalatinsk nuclear test site on this territory, leads to the need for further research to improve the prediction of the treatment process of patients with cancer.

Currently, the method of radioiodotherapy presented in the work is actively used for the treatment of oncological diseases, and in particular thyroid cancer. This method of treatment allows you to destroy cancer cells, surgical removal of which is not possible. An accurate calculation of the activity of the drug to be taken by the patient allows you to reduce the dose load on the patient and at the same time achieve the desired therapeutic effect. The paper presents formulas that are used to calculate the radiation dose of patients for the successful treatment of thyroid cancer. This method of treatment is carried out in the department of "Radionuclide Therapy" of the Center for Nuclear Medicine and Oncology of Semey.

1. https://www.inform.kz/ru/svyshe-194-tys-kazahstancev-stradayut-ot-onkozabolevaniy_a3922896

2. https://yk-news.kz/news/В-ВКО-увеличилось-количество-онкологических-больных.

3. https://www.google.com/search?client=opera&q=дадиойодтерапия&sourceid=opera&ie=UTF-8&oe=UTF-8

4. Belikhina T.I., Sandybaev M.T., Atantayeva B.Zh., Esbolatova N.S. The first experience of radioiodine therapy in patients with differentiated forms of thyroid cancer. abstract VIII Congress of oncologists and radiologists of Kazakhstan with int. uch. - Turkestan. – 2021

5. Danilova L.I., Valuyevich V.V. Radioiodine therapy for benign thyroid diseases. Problems of Endocrinology. 2006;52(2):43-47. (In Russ.) https://doi.org/10.14341/probl200652243-47

6. Braga M., Walpert N, Burch H. B. et al.//Thyroid. -2002. -Vol. 12. -P. 135-139.

7. Farkhutdinova L.M. RADIOIODINE THERAPY OF PAPILLARY THYROID CANCER, COMPLICATED BY A RADIAL MYELITIS. CLINICAL CASE. The Russian Archives of Internal Medicine. 2018;8(3):223-230. https://doi.org/10.20514/2226-6704-2018-8-3-223-230

8. Mountford P.J., Temperton D.H. Recommendations of the International Commission on Radiological Protection 1990 // Eur. J. Nucl. Med. 1992. No 9, 77-79.

9. Vanushko V.E., Kuznetsov N.S., Garbuzov P.I., Fadeev V.V. Thyroid cancer // Problems of endocrinology. 2005, V.51, No. 4. pp.43-53.

10. Garbuzov P.I. Algorithms for the diagnosis and treatment of highly differentiated thyroid cancer. Clinical thyroidology. 2003. V.1, No. 3, S.63-67.

11. “Sanitary and epidemiological requirements for ensuring radiation safety” dated February 27, 2015 №155. Registered with the Ministry of Justice of the Republic of Kazakhstan on April 10, 2015 №10671.

12. “Sanitary and epidemiological requirements for radiation hazardous facilities” dated March 27, 2015 №260. Registered with the Ministry of Justice of the Republic of Kazakhstan on June 5, 2015 №11204.

13.