kaz44Вестник Университета Шакарима. Серия технические наукиBulletin of Shakarim University. Technical Sciences2788-79953006-0524«Шәкәрім университеті» КеАҚ10.53360/2788-7995-2024-4(16)-32kaz44-1414Research ArticleПИЩЕВАЯ ИНЖЕНЕРИЯ И БИОТЕХНОЛОГИЯ (ОРИГИНАЛЬНАЯ СТАТЬЯ)FOOD ENGINEERING AND BIOTECHNOLOGY (ORIGINAL ARTICLE)СОВРЕМЕННЫЕ ДОСТИЖЕНИЯ В ПРИМЕНЕНИИ ЦЕЛЛЮЛОЗОЛИТИЧЕСКИХ МИКРООРГАНИЗМОВ ДЛЯ ПЕРЕРАБОТКИ ЛИГНОЦЕЛЛЮЛОЗНОЙ БИОМАССЫMODERN ACHIEVEMENTS IN THE USE OF CELLULOLYTIC MICROORGANISMS FOR PROCESSING LIGNOCELLULOSE BIOMASShttps://orcid.org/0000-0001-8323-3982ИсаеваА. У.IssayevaA. U.

Акмарал Умурбековна Исаева – доктор биологических наук, профессор, директор НИИ Экологии и биологии

160031, Республика Казахстан, г. Шымкент, Каратауский район, ул. Жибек жолы, земельный участок № 6 

Akmaral Umurbekovna Issayeva – Doctor of Biological Sciences, Professor. Director of the Research Institute of Ecology and Biology 

160031, Republic of Kazakhstan, Shymkent, Karatau district, Zhibek Zholy street, land plot № 6 

akissayeva@mail.ruhttps://orcid.org/0000-0002-8231-1982КаримоваС. С.KarimovaS. S.

Саулет Сабитхановна Каримова – постдокторант, старший научный сотрудник НИИ Экологии и биологии

160031, Республика Казахстан, г. Шымкент, Каратауский район, ул. Жибек жолы, земельный участок № 6 

Saulet Sabitkhanovna Karimova – postdoctoral fellow, Senior Researcher at the Research Institute of Ecology and Biology 

160031, Republic of Kazakhstan, Shymkent, Karatau district, Zhibek Zholy street, land plot № 6 

saulet_ka@mail.ruЖумадулаеваА. И.ZhumadulaevaA. I.

Алиса Исаевна Жумадулаева – кандидат сельскохозяйственных наук, старший преподавателькафедры естественных наук

160031, Республика Казахстан, г. Шымкент, Каратауский район, ул. Жибек жолы, земельный участок № 6 

Alisa Issayevna Zhumadulayeva – Candidate of Agricultural Sciences, Senior Lecturer at the Department of Natural Sciences 

160031, Republic of Kazakhstan, Shymkent, Karatau district, Zhibek Zholy street, land plot № 6 

alisa195858@mail.ruАралбаеваР. Б.AralbayevaR. B.

Райхан Бурахановна Аралбаева – магистр, старший преподаватель кафедры естественных наук

160031, Республика Казахстан, г. Шымкент, Каратауский район, ул. Жибек жолы, земельный участок № 6 

Raykhan Burakhanovna Aralbayeva – Master's degree, Senior Lecturer at the Department of Natural Sciences 

160031, Republic of Kazakhstan, Shymkent, Karatau district, Zhibek Zholy street, land plot № 6 

raihan-14.88@mail.ruАширбаеваС. Б.AshirbayevaS. B.

Салтанат Бибатровна Аширбаева – магистр, старший преподаватель кафедры естественных наук

160031, Республика Казахстан, г. Шымкент, Каратауский район, ул. Жибек жолы, земельный участок № 6 

Saltanat Bibatrovna Ashirbayeva – Master's degree, Senior Lecturer at the Department of Natural Sciences 

160031, Republic of Kazakhstan, Shymkent, Karatau district, Zhibek Zholy street, land plot № 6 

salta_12.58@mail.ruШымкентский УниверситетКазахстанShymkent UniversityKazakhstan20242712202414(16)243254Copyright © Исаева А.У., Каримова С.С., Жумадулаева А.И., Аралбаева Р.Б., Аширбаева С.Б., 20252025Исаева А.У., Каримова С.С., Жумадулаева А.И., Аралбаева Р.Б., Аширбаева С.Б.Issayeva A.U., Karimova S.S., Zhumadulaeva A.I., Aralbayeva R.B., Ashirbayeva S.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://tech.vestnik.shakarim.kz/jour/article/view/1414

Лигноцеллюлозная биомасса (ЛЦБ) представляет собой важный ресурс для получения биотоплива и других высокоценных продуктов. Основными компонентами ЛЦБ являются целлюлоза и лигнин, которые сложно разлагаются. Исследования последних лет сосредоточились на применении целлюлозолитических микроорганизмов, таких как бактерии Bacillus subtilis, грибы Trichoderma reesei и Penicillium oxalicum, для эффективного расщепления этих компонентов. В статье представлен обзор современных достижений, включая применение глубоких эвтектических растворителей (DES), что показало улучшение доступности целлюлозы и повышение выхода сахаров до 80%. Применение агропромышленных отходов, таких как рисовая солома, в качестве субстрата для производства ферментов, способствует снижению стоимости производства и поддерживает циркулярную биоэкономику.Описаны стратегии повышения эффективности ферментативной переработки,  включая разработку мультиферментных комплексов и генетически модифицированных штаммов микроорганизмов. Например, использование многофункциональных ферментов из Clostridium cellulosi позволило увеличить выход сахаров на 30%. Рассмотрены возможности интеграции ко-культур грибов и гидротермальных методов обработки, которые обеспечивают синергетический эффект в переработке ЛЦБ.Особое внимание уделено ключевым ферментам, таким как целлюлазы, гемицеллюлазы и лигниназы, и их роли в расщеплении растительных полимеров. Обсуждаются перспективы дальнейших исследований, включая разработку термостабильных ферментов, внедрение экологически чистых методов обработки и интеграцию новых технологий в промышленные биорефинерии.

Lignocellulose biomass (LCB) is an important resource for the production of biofuels and other highvalue products. The main components of LCB are cellulose and lignin, which are difficult to decompose. Recent research has focused on the use of cellulolytic microorganisms, such as Bacillus subtilis bacteria, Trichoderma reesei fungi and Penicillium oxalicum, to effectively break down these components. The article provides an overview of modern achievements, including the use of deep eutectic solvents (DES), which showed an improvement in the availability of cellulose and an increase in sugar yield up to 80%. The use of agro-industrial waste, such as rice straw, as a substrate for the production of enzymes, helps to reduce the cost of production and supports circular bioeconomics.Strategies to increase the efficiency of enzymatic processing are described, including the development of multi-enzyme complexes and genetically modified strains of microorganisms. For example, the use of multifunctional enzymes from Clostridium cellulosi allowed to increase the yield of sugars by 30%. The possibilities of integrating mushroom co-cultures and hydrothermal processing methods that provide a synergistic effect in the processing of LCB are considered.Special attention is paid to key enzymes such as cellulases, hemicellulases and ligninases and their role in the breakdown of plant polymers. Prospects for further research are discussed, including the development of thermostable enzymes, the introduction of environmentally friendly processing methods and the integration of new technologies into industrial biorefineries.

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The authors declare that there are no conflicts of interest present.