<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">kaz44</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник Университета Шакарима. Серия технические науки</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of Shakarim University. Technical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2788-7995</issn><issn pub-type="epub">3006-0524</issn><publisher><publisher-name>«Шәкәрім университеті» КеАҚ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.53360/2788-7995-2024-3(15)-23</article-id><article-id custom-type="elpub" pub-id-type="custom">kaz44-1177</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПИЩЕВАЯ ИНЖЕНЕРИЯ И БИОТЕХНОЛОГИЯ (ОРИГИНАЛЬНАЯ СТАТЬЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FOOD ENGINEERING AND BIOTECHNOLOGY (ORIGINAL ARTICLE)</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ФУНКЦИОНАЛЬНЫХ ПРОДУКТОВ НА БИОМАРКЕРЫ ДИАГНОСТИРУЮЩИЕ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ</article-title><trans-title-group xml:lang="en"><trans-title>THE EFFECT OF FUNCTIONAL PRODUCTS ON BIOMARKERS DIAGNOSING CARDIOVASCULAR DISEASES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Темиржанова</surname><given-names>З. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Temirzhanova</surname><given-names>Z. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Зухра Нуржановна Темиржанова – магистр технических наук, докторант,</p><p>140008, г. Павлодар, ул. Ломова, 64</p></bio><bio xml:lang="en"><p>Zukhra Nurzhanovna Temirzhanova – Master of Technical Sciences, doctoral student ; Specialist of the Center for Commercialization and Innovation,</p><p>140008, Pavlodar, st. Lomova, 64</p></bio><email xlink:type="simple">zukhra_94g@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куралай Сметкановна Исаева – кандидат технических наук, ассоц. профессор,</p><p>140008, г. Павлодар, ул. Ломова, 64</p></bio><bio xml:lang="en"><p>Kuralai Smetkanovna Isaeva – Candidate of Technical Sciences, Associate Professor,</p><p>140008, Pavlodar, st. Lomova, 64</p></bio><email xlink:type="simple">zukhra_94g@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Торайгыров университет<country>Казахстан</country></aff><aff xml:lang="en">Toraigyrov University<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2024</year></pub-date><volume>0</volume><issue>3(15)</issue><fpage>169</fpage><lpage>177</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Темиржанова З.Н., Исаева К.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Темиржанова З.Н., Исаева К.С.</copyright-holder><copyright-holder xml:lang="en">Temirzhanova Z.N., Isaeva K.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://tech.vestnik.shakarim.kz/jour/article/view/1177">https://tech.vestnik.shakarim.kz/jour/article/view/1177</self-uri><abstract><p>Функциональные продукты питания и их биологически активные соединения широко изучались как группа продуктов, имеющих большое значение для предотвращения развития хронических заболеваний. Сердечно-сосудистые заболевания является глобальной проблемой здравоохранения, которую можно облегчить с помощью функциональных пищевых продуктов. Снижения риска сердечно-сосудистых заболевания может быть измерен с помощью специфических биомаркеров сердечно-сосудистых заболеваний, таких как липидный профиль, функция эндотелия, активация тромбоцитов, гемостаз и биомаркер воспаления. Некоторые функциональные биологически активные соединения могут играть важную роль в профилактике и лечении сердечно-сосудистых заболеваний, благотворно влияя на уровни этих биомаркеров.</p><p>Целью данного исследования было изучить влияние функциональных продуктов на биомаркеров сердечно-сосудистых заболеваний, а также возможное улучшение показателей при приеме функциональной пищевой смеси.</p><p>Методы: Поиск литературы для выявления статей проводился с использованием PubMed, Science Direct.</p><p>Результаты были проанализированы двадцать семь публикаций. Во всех этих публикациях сообщалось о положительном влиянии функциональных продуктов на биомаркер. Чаще всего отмечались положительные результаты от применения соевых продуктов, молочные продукты, гранат, клюквы и вегетарианские диеты и диета Окинава.</p></abstract><trans-abstract xml:lang="en"><p>Functional foods and their biologically active compounds have been widely studied as a group of foods of great importance for preventing the development of chronic diseases. Cardiovascular disease is a global health problem that can be alleviated with functional foods. The reduction in the risk of cardiovascular disease can be measured using specific biomarkers of cardiovascular disease, such as lipid profile, endothelial function, platelet activation, hemostasis and biomarkers of inflammation. Some functional biologically active compounds may play an important role in the prevention and treatment of cardiovascular diseases, beneficially affecting the levels of these biomarkers.</p><p>The purpose of this study was to study the effect of functional foods on biomarkers of cardiovascular diseases, as well as the possible improvement of indicators when taking a functional food mixture.</p><p>Methods: A literature search to identify articles was conducted using PubMed, Science Direct.</p><p>The results were analyzed in twenty-seven publications. In all these publications, the positive effect of functional products on biomarkers has been reported. Most often, positive results were noted from the use of soy products, dairy products, pomegranates, cranberries and vegetarian diets and the Okinawa diet.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>функциональные продукты питания</kwd><kwd>биомаркеры</kwd><kwd>холестерин</kwd><kwd>липопротеин высокой плотности</kwd><kwd>соевые продукты</kwd><kwd>молочные продукты</kwd><kwd>гранат</kwd><kwd>клюква</kwd><kwd>диета Окинава</kwd><kwd>вегетарианская диета</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>functional foods</kwd><kwd>biomarkers</kwd><kwd>cholesterol</kwd><kwd>high-density lipoprotein</kwd><kwd>soy products</kwd><kwd>dairy products</kwd><kwd>pomegranate</kwd><kwd>cranberries</kwd><kwd>Okinawa diet</kwd><kwd>vegetarian diet</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бекбергенова Ж.Б. Руководство для медицинских сестер расширенной практики по оценке риска и профилактике сердечно-сосудистых заболеваний / Ж.Б. Бекбергенова, А.Т. Умбетжанова. – Нур-Султан: Республиканский центр развития здравоохранения, 2019. – 72 с.</mixed-citation><mixed-citation xml:lang="en">Bekbergenova ZH.B. Rukovodstvo dlya meditsinskikh sester rasshirennoi praktiki po otsenke riska i profilaktike serdechno-sosudistykh zabolevanii / ZH.B. Bekbergenova, A.T. Umbetzhanova. – Nur-Sultan: Respublikanskii tsentr razvitiya zdravookhraneniya, 2019. – 72 s. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hajjo R. Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers / R. Hajjo, D.A. Sabbah, A.Q.Al Bawab // Diagnostics. – 2022. – № 12(7). – Р. 1742. https://doi.org/10.3390/diagnostics12071742.</mixed-citation><mixed-citation xml:lang="en">Hajjo R. Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers / R. Hajjo, D.A. Sabbah, A.Q.Al Bawab // Diagnostics. – 2022. – № 12(7). – R. 1742. https://doi.org/10.3390/diagnostics12071742. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinidi M. Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity's Metabolic Consequences. / M. Konstantinidi, E.A. Koutelidakis // Medicines (Basel). – 2019. – № 6(3)94. https://doi:10.3390/medicines6030094.</mixed-citation><mixed-citation xml:lang="en">Konstantinidi M. Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity's Metabolic Consequences. / M. Konstantinidi, E.A. Koutelidakis // Medicines (Basel). – 2019. – № 6(3)94. https://doi:10.3390/medicines6030094. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Halford J.C.G. Satiety-enhancing products for appetite control: science and regulation of functional foods for weight management / J.C.G. Halford, J.A. Harrold // Published online by Cambridge University Press. – 2012. http://doi:10.1017/S0029665112000134.</mixed-citation><mixed-citation xml:lang="en">Halford J.C.G. Satiety-enhancing products for appetite control: science and regulation of functional foods for weight management / J.C.G. Halford, J.A. Harrold // Published online by Cambridge University Press. – 2012. http://doi:10.1017/S0029665112000134. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Antonios E.K. The effects of functional food and bioactive compounds on biomarkers of cardiovascular diseases / E.K. Antonios // Functional Foods Textbook. Martirosyan D. (Εd.). Functional Food Center, U.S.A. 1st Edition. – Р. 89-117.</mixed-citation><mixed-citation xml:lang="en">Antonios E.K. The effects of functional food and bioactive compounds on biomarkers of cardiovascular diseases / E.K. Antonios // Functional Foods Textbook. Martirosyan D. (Εd.). Functional Food Center, U.S.A. 1st Edition. – R. 89-117. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kutelidakis A.E. The effect of functional foods and biologically active compounds on biomarkers of cardiovascular diseases / A.E. Kutelidakis // Center for Functional Nutrition, USA, 1st edition. – Р. 89-117.</mixed-citation><mixed-citation xml:lang="en">Kutelidakis A.E. The effect of functional foods and biologically active compounds on biomarkers of cardiovascular diseases / A.E. Kutelidakis // Center for Functional Nutrition, USA, 1st edition. – R. 89-117. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gut health: predictive biomarkers for preventive medicine and development of functional foods / R. Oozeer et al // Published online by Cambridge University Press. – 2010. http://doi:10.1017/S0007114509993400.</mixed-citation><mixed-citation xml:lang="en">Gut health: predictive biomarkers for preventive medicine and development of functional foods / R. Oozeer et al // Published online by Cambridge University Press. – 2010. http://doi:10.1017/S0007114509993400. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bjursell M.K. Gordon Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period / M.K. Bjursell, E.C. Martens, J.I. Gordon // J Biol Chem. – 2006. – № 281(47). http://doi:10.1074/jbc.M606509200.</mixed-citation><mixed-citation xml:lang="en">Bjursell M.K. Gordon Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period / M.K. Bjursell, E.C. Martens, J.I. Gordon // J Biol Chem. – 2006. – № 281(47). http://doi:10.1074/jbc.M606509200. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Early differences in fecal microbiota composition in children may predict overweight / K.M. Collado et al // Am J Clin Nutr. – 2008. – № 87. – Р. 534-538.</mixed-citation><mixed-citation xml:lang="en">Early differences in fecal microbiota composition in children may predict overweight / K.M. Collado et al // Am J Clin Nutr. – 2008. – № 87. – R. 534-538. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Obesity alters gut microbial ecology / R.E. Ley et al // Proc Natl Acad Sci USA. – 2008. – № 102. – Р. 11070-11075.</mixed-citation><mixed-citation xml:lang="en">Obesity alters gut microbial ecology / R.E. Ley et al // Proc Natl Acad Sci USA. – 2008. – № 102. – R. 11070-11075. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America / C.W. Yancy et al // Circulation. – 2017. – № 136(6). – Р. e137–61. http://doi:10.1161/CIR.0000000000000509.</mixed-citation><mixed-citation xml:lang="en">A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America / C.W. Yancy et al // Circulation. – 2017. – № 136(6). – R. e137–61. http://doi:10.1161/CIR.0000000000000509. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson S.E. Personalized cancer medicine / S.E. Jackson, D.D. Chester // Int J Cancer. – 2015. – № 137(2). – Р. 262-6. https://doi.org/10.1002/ijc.28940.</mixed-citation><mixed-citation xml:lang="en">Jackson S.E. Personalized cancer medicine / S.E. Jackson, D.D. Chester // Int J Cancer. – 2015. – № 137(2). – R. 262-6. https://doi.org/10.1002/ijc.28940. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">van Vollenhoven R.F. Personalized medicine in rheumatology / R.F. van Vollenhoven, M. L'ami, G. Wolbink // The Psychiatrist is a psychiatrist. – 2018. – № 60(3). – Р. 146-50.</mixed-citation><mixed-citation xml:lang="en">van Vollenhoven R.F. Personalized medicine in rheumatology / R.F. van Vollenhoven, M. L'ami, G. Wolbink // The Psychiatrist is a psychiatrist. – 2018. – № 60(3). – R. 146-50. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Narod S.A. Personalized medicine and public health: breast and ovarian cancer / S.A. Narod // Hum Genet. – 2018. – № 137(10). – Р. 769-778. https://doi.org/10.1007/s00439-018-1944-6.</mixed-citation><mixed-citation xml:lang="en">Narod S.A. Personalized medicine and public health: breast and ovarian cancer / S.A. Narod // Hum Genet. – 2018. – № 137(10). – R. 769-778. https://doi.org/10.1007/s0043 9-018-1944-6. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Changes in the human intestinal microbiome in cirrhosis of the liver / N. Qin et al // Nature. – 2014. – № 513(7516). – Р. 59-64. https://doi.org/10.1038/nature13568.</mixed-citation><mixed-citation xml:lang="en">Changes in the human intestinal microbiome in cirrhosis of the liver / N. Qin et al // Nature. – 2014. – № 513(7516). – R. 59-64. https://doi.org/10.1038/natur e13568. (In English).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Multiplex protein platforms based on antibodies: technical and operational problems / А.А. Ellington et al // Clinical Chemistry. – 2010. – № 56(2). – Р. 186-193. https://doi.org/10.1373/clinchem.2009.127514.</mixed-citation><mixed-citation xml:lang="en">Multiplex protein platforms based on antibodies: technical and operational problems / А.А. Ellington et al // Clinical Chemistry. – 2010. – № 56(2). – Р. 186-193. https://doi.org/10.1373/clinchem.2009.127514.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Muzafar H.M. Efficacy of functional foods mixture in improving hypercholesterolemia, inflammatory and endothelial dysfunction biomarkers-induced by high cholesterol diet / H.M. AlMuzafar, K.A. Amin // Lipids in Health and Disease. – 2017. – Vol. 16, № 194. https://doi.org/10.1186/s12944-017-0585-4.</mixed-citation><mixed-citation xml:lang="en">Al-Muzafar H.M. Efficacy of functional foods mixture in improving hypercholesterolemia, inflammatory and endothelial dysfunction biomarkers-induced by high cholesterol diet / H.M. AlMuzafar, K.A. Amin // Lipids in Health and Disease. – 2017. – Vol. 16, № 194. https://doi.org/10.1186/s12944-017-0585-4.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">The effect of an intensive lifestyle change program on the thickness of the intima media of the carotid artery: a randomized study / S.G. Aldana et al // American Journal of Health Promotion. – 2007. – Vol. 21, № 6. – Р. 510-516.</mixed-citation><mixed-citation xml:lang="en">The effect of an intensive lifestyle change program on the thickness of the intima media of the carotid artery: a randomized study / S.G. Aldana et al // American Journal of Health Promotion. – 2007. – Vol. 21, № 6. – Р. 510-516.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy K.S. Diet, proper nutrition and prevention of hypertension and cardiovascular diseases / K.S. Reddy, M.B. Katan // Nutrition for public health. – 2004. – Vol. 7, № 1. – Р. 167-186. https://doi.org/10.1079/PHN2003587.</mixed-citation><mixed-citation xml:lang="en">Reddy K.S. Diet, proper nutrition and prevention of hypertension and cardiovascular diseases / K.S. Reddy, M.B. Katan // Nutrition for public health. – 2004. – Vol. 7, № 1. – Р. 167-186. https://doi.org/10.1079/PHN2003587.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Consumption of whole grains, bran and germ and the risk of coronary heart disease in men / M.K. Jensen et al // American Journal of Clinical Nutrition. –2004. – Vol. 80, № 6. – Р. 1492-1499.</mixed-citation><mixed-citation xml:lang="en">Consumption of whole grains, bran and germ and the risk of coronary heart disease in men / M.K. Jensen et al // American Journal of Clinical Nutrition. –2004. – Vol. 80, № 6. – Р. 1492-1499.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gee H. A systematic review, meta-analysis and reanalysis of the results of randomized controlled trials that report an association between the consumption of about 25 g of soy protein per day and blood cholesterol levels / H. Gee, H. TA // Atherosclerosis. – 2008. – № 200(1). – Р. 13-27.</mixed-citation><mixed-citation xml:lang="en">Gee H. A systematic review, meta-analysis and reanalysis of the results of randomized controlled trials that report an association between the consumption of about 25 g of soy protein per day and blood cholesterol levels / H. Gee, H. TA // Atherosclerosis. – 2008. – № 200(1). – Р. 13-27.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Development of functional yogurt using freeze-drying on powders from soy peel and mung beans / M. Salim et al // Before. Support. The food system. – 2023. – № 7. – Р. 1083389. https://doi.org/10.3389/fsufs.2023.1083389.</mixed-citation><mixed-citation xml:lang="en">Development of functional yogurt using freeze-drying on powders from soy peel and mung beans / M. Salim et al // Before. Support. The food system. – 2023. – № 7. – Р. 1083389. https://doi.org/10.3389/fsufs.2023.1083389.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
